Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses

Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses

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Summary: Persistent viral infections subvert key elements of adaptive immunity.To compare germinal center (GC) B cell responses in chronic and acute lymphocytic choriomeningitis virus infection, we exploit activation-induced deaminase (AID) fate-reporter mice and perform adoptive B cell transfer experiments.Chronic infection yields GC B cell responses of higher cellularity than SERENITY FORMULA acute infections do, higher memory B cell and antibody secreting cell output for longer periods of time, a better representation of the late B cell repertoire in serum immunoglobulin, and higher titers of protective neutralizing antibodies.GC B cells of chronically infected mice are similarly hypermutated as those emerging from acute infection.

They efficiently adapt to viral escape variants and even in hypermutation-impaired AID mutant mice, chronic infection selects for GC B cells with Dryer Filter Grille hypermutated B cell receptors (BCRs) and neutralizing antibody formation.These findings demonstrate that, unlike for CD8+ T cells, chronic viral infection drives a functional, productive, and protective GC B cell response.: Fallet et al.used AID fate-mapping to compare germinal center responses to chronic and acute viral infection.

Germinal center B cells in chronic infection hypermutate efficiently, adapt to viral variants, and yield more antibody-secreting cells and memory B cells for longer time periods than found in acute infection, enabling neutralizing antibody formation.Keywords: chronic viral infection, germinal center B cells, neutralizing antibody, affinity maturation, lymphocytic choriomeningitis virus, LCMV, AID, memory B cell, antibody-secreting cell.